. Author manuscript; available in PMC: 2015 Jul 1.

Published in final edited form as: Alzheimer Dis Assoc Disord. 2014 Jul-Sep;28(3):219–225. doi: 10.1097/WAD.0000000000000032

Table 4.

Linear regression model of neuropathology and brain MRI results, adjusted for age, interval between MRI and autopsy, and gender (n = 59, significant values in bold).

Pathology		TCBV		LWMHV		HPV		LTHV
Pathology		beta±SE	p-value	beta±SE	p-value	beta±SE	p-value	beta±SE	p-value
NFT	Total	−0.02±0.01	0.003	0.01±0.01	0.409	−0.02±0.01	0.079	0.03±0.01	0.001
	Cortical	−0.04±0.01	0.004	0.01±0.01	0.641	−0.03±0.02	0.044	0.05±0.01	0.001
	MTL	−0.06±0.04	0.080	0.04±0.04	0.257	−0.03±0.04	0.500	0.11±0.04	0.003
Braak stage		−0.15±0.06	0.016	0.03±0.06	0.567	−0.11±07	0.123	0.22±0.06	0.001
NP	Total	−0.03±0.01	0.010	−0.001±0.01	0.895	−0.02±0.01	0.124	0.03±0.01	0.001
	Cortical	−0.04±0.01	0.004	−0.001±0.02	0.934	−0.03±0.02	0.110	0.06±0.02	0.001
	MTL	−0.05±0.03	0.073	−0.01±0.03	0.844	−0.04±0.03	0.204	0.07±0.03	0.013
Atherosclerosis		−0.05±0.03	0.099	−0.01±0.03	0.802	−0.03±0.04	0.489	0.05±0.03	0.154
IIS		−0.20±0.12	0.105	−0.01±0.12	0.948	−0.22±0.14	0.110	0.20±0.13	0.142
VIS		−0.12±0.13	0.364	0.03±0.12	0.832	−0.001±0.14	0.995	0.10±0.14	0.453
Chronic infarcts^*		−0.21±0.35	0.554	0.06±0.34	0.859	0.02±0.39	0.964	0.13±0.38	0.727
Chronic lacunes^*		−0.10±0.29	0.728	−0.22±0.28	0.437	−0.06±0.33	0.863	0.01±0.31	0.964
Total micro-infarcts^*		−0.19±0.22	0.380	0.24±0.21	0.261	0.39±0.24	0.106	−0.20±0.23	0.394
Noncavitated microinfarcts^*		−0.03±0.24	0.899	0.08±0.24	0.732	0.64±0.26	0.015	−0.39±0.26	0.138
Cavitated microinfarcts^*		−0.17±0.22	0.440	0.25±0.21	0.245	0.35±0.24	0.149	−0.11±0.24	0.653
Cortical micro-infarcts^*		−0.02±0.25	0.943	−0.09±0.24	0.706	0.31±0.27	0.249	−0.16±0.26	0.534
Subcortical microinfarcts^*		−0.11±0.25	0.670	0.004±0.24	0.987	0.57±0.27	0.036	−0.32±0.26	0.225
Deep nucleii microinfarcts^*		−0.10±0.23	0.669	0.53±0.21	0.016	0.26±0.26	0.308	−0.09±0.25	0.715
Hippocampal Sclerosis^*		---	---	---	---	−1.23 ± 0.30	<0.001	0.44±0.33	0.179

Abbreviations: MRI, magnetic resonance imaging; NFT, neurofibrillary tangle; MTL, medial temporal lobe; CERAD, Consortium to Establish a Registry of Alzheimer's disease; TCBV, total cerebral brain volume; LWMHV, logarithm of white matter hyperintensity volume; HPV, hippocampal volume; LTHV, logarithm of temporal horn volume; NP, neuritic plaque; IIS, ischemic injury score; VIS, vascular ischemic score

Given the distribution of scores, these pathology variables were analyzed as present or absent.