Table 1.
List of enriched gene ontology terms associated with DENV responsive genes. The number of response genes associated with each GO term and the total number of genes associated with the same term are listed. The p-value represents the hypergeometric distribution p-value calculated for each GO term as described in Behura et al. (2011).
| GO Term Name | No. of responsive genes | Total no. of genes | p-value |
|---|---|---|---|
| Protein binding | 37 | 2429 | 0.040 |
| Nucleotide binding | 17 | 877 | 0.027 |
| Binding | 14 | 749 | 0.044 |
| Metabolic process | 14 | 689 | 0.030 |
| Integral to membrane | 9 | 1143 | 0.035 |
| Nucleic acid binding | 9 | 1133 | 0.037 |
| Kinase activity | 8 | 355 | 0.049 |
| Nucleus | 8 | 1033 | 0.039 |
| Protein kinase activity | 7 | 247 | 0.027 |
| Protein phosphorylation | 7 | 256 | 0.030 |
| Protein serine/threonine kinase activity | 7 | 250 | 0.028 |
| GTP binding | 5 | 159 | 0.038 |
| GTPase activity | 5 | 96 | 0.007 |
| RNA binding | 5 | 164 | 0.042 |
| Acid-amino acid ligase activity | 4 | 49 | 0.003 |
| Protein modification process | 3 | 39 | 0.012 |
| Protein ubiquitination | 3 | 28 | 0.005 |
| Translation elongation factor activity | 3 | 20 | 0.002 |
| Ubiquitin-protein ligase activity | 3 | 33 | 0.008 |
| DNA recombination | 2 | 17 | 0.019 |
| Glycolysis | 2 | 20 | 0.025 |
| Regulation of protein metabolic process | 2 | 28 | 0.045 |
| Small conjugating protein ligase activity | 2 | 28 | 0.045 |
| Translational elongation | 2 | 21 | 0.027 |