Skip to main content
. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Mucosal Immunol. 2014 Mar 12;7(5):1255–1265. doi: 10.1038/mi.2014.15

Figure 5. E2 signaling is protective against ileitis in SAMP-M mice.

Figure 5

(A,B,C) 10-wk-old GDX-SAMP mice were administered vehicle (Ctrl), E2 (10 ug/kg), PPT (10 mg/kg), or DPN (10 mg/kg) by i.p injection. Following 6 weeks of treatment, MLNs were harvested and cells stained for flow cytometry. Representative histograms are shown in (A) and percentages of CD25+Foxp3+ cells among CD4-gated lymphocytes are expressed as mean ± SEM (*p<0.05, **p<0.01, n=6/group) (B). (C) Total Inflammatory scores are represented as mean ± SEM (*p≤0.05, n=8–14/group). (D) 10-wk-old GDX-SAMP were implanted with subcutaneous estrogen for 6 wks (see Materials & Methods). Total inflammatory scores following 6 weeks of indicated hormone treatment (expressed as mean ± SEM, *p<0.05, n=6/group).