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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Leukemia. 2014 Feb 20;28(9):1819–1827. doi: 10.1038/leu.2014.78

Figure 7.

Figure 7

BIM mediates T-ALL regression following MYC inactivation in vivo. (a and c) One representative rag2:MYC-ER;rag2:EGFP double-transgenic, bim wild-type zebrafish, shown at the time of T-ALL onset (a) and 8 weeks after removal from 4HT (c). (b and d) One rag2:MYC-ER; rag2:EGFP double-transgenic zebrafish that harbored homozygous mutations of bim, shown at time of T-ALL onset (b) and 8 weeks after removal from 4-hydroxytamoxifen (d). (e) Quantitation of T-ALL persistence after downregulation of MYC by removal from 4-hydroxytamoxifen. P value was calculated using a Kruskal-Wallis test. (f) Proposed model to explain our findings.