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A. IHC shows normal pericentral expression of GS, Cyp1a2 and Cyp2e1 in Con livers, while absence of these proteins is observed in littermate Lrp-LKO livers.
B. When injected with lethal dose of APAP (600 mg/kg body weight), Lrp-LKO showed significantly lower ALT and AST levels than Con after 24 hours.
