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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Hepatology. 2014 Jul 25;60(3):964–976. doi: 10.1002/hep.27082

Figure 8. Dampened LR in Wls-MKO after PH.

Figure 8

A. IHC (200×) showing many PCNA-positive hepatocytes in Con livers at 40 hours and 72 hours; however several PCNA-negative hepatocytes were observed in Wls-MKO at 40 hours.

B. Quantification of PCNA staining showing a 33% and significant decease in the number of hepatocytes in S-phase in Wls-MKO at 40 hours (**p<0.01).

C. Quantification of mitotic figures shows a significantly lower numbers in Lrp-LKO as compared at Con at 72 hours after PH. (*p<0.05)

D. Representative WB shows lower Cyclin-D1 levels in Wls-MKO at 40 hours after PH.

E. A representative immunoprecipitation study shows decreased TCF4-β-catenin complex formation at 4 hours after PH in Wls-Mac KO when compared to Con. Immunoprecipitation studies were performed by pull down of either β-catenin or TCF4. Respective input controls are included in analysis as well.