Fig. 6.
APP−/− and wild type peritoneal macrophage demonstrated different cytokine secretory profiles compared to intestinal macrophage. Non-elicited peritoneal macrophage and intestinal macrophage were isolated from C57BL6/J wild type and APP−/− mice. Macrophage were stimulated with or without 25ng/mL LPS, 24hr in serum-free DMEM/F12. Media was collected to quantify basal and stimulated secretion of KC, IL-6, RANTES and IL-1β. The results are displayed as mean (+/−SD) from 6 animals in each group *p<0.05, **p<0.01, ***p<0.001.