Small intestine of APP−/− mice demonstrated altered levels of multiple cytokines compared wild type controls. Ileum from C57BL6/J wild type and APP−/− mice were collected, lysed, and used in an antibody cytokine array. APP−/− mice demonstrated decreased CD30L, eotaxin, fas ligand, fractalkine, GCSF, IL-10, IL-12p40p70, IL-3, IL-9, MIG, MIP-1γ, and sTNFRI compared to wild type mice. A representative array for one animal from each genotype is shown. Optical densities of normalized dot intensities from 6 animals in each group are displayed as mean (+/−SD). *p<0.05