Table 4.

Impact of chemotherapy delivery on disease-free survival

DFS	Survival probability (%)
	<2 cycles (n = 216)	≥2 cycles (n = 15)	<15 days (n = 226)	≥15 days (n = 5)	≥85 % RDI (n = 226)	<85 % RDI (n = 5)	Overall % (95 % CI)
2 years	99	93	98	100	99	80	98 (97–100)
p	0.126		0.765		0.001*
4 years	91	93	91	100	91	80	91 (87–95)
p	0.791		0.491		0.315
5 years	88	93	88	100	88	80	88 (84–92)
p	0.562		0.418		0.500
6 years	86	93	86	100	87	80	87 (82–91)
p	0.473		0.375		0.563
8 years	84	93	85	100	85	80	84 (79–90)
p	0.465		0.366		0.621
10 years	79	93	79	100	80	80	80 (72–87)
p	0.418		0.323		0.695

CI confidence interval, DFS disease-free survival, RDI relative dose intensity

* Statistically significant