Fig. 4.

Differentially expressed miRNAs determined by qRT-PCR. 3D6_H, CHO 3D6scFv-Fc high producer; 3D6_L, CHO 3D6scFv-Fc low producer; HSA_H, CHO HSA high producer; HSA_L, CHO HSA low producer; EV, CHO empty vector (non-producer). qRT-PCR data were normalized using two endogenous controls (miR-185-5p and Actr5). The software REST 2009 was used to calculate relative expression ratios and for statistical analysis (*p < 0.05, **p < 0.01, ***p < 0.005). Data represent mean values of three independent steady-state cultivations (error bars SE)