Table 2.

Enrichment analysis of negatively correlated miRNA targets

miRNA	Number of negatively correlated differentially expressed genesa	Number of differentially expressed targets		Number of negatively correlated differentially expressed targets		Odds ratio (OR)b		p value (Fisher’s exact test)c
		Predicted	Validated	Predicted	Validated	Predicted targets	Validated targets	Predicted targets	Validated targets
let-7b-5p	237	169	205	19	16	1.392	0.931	0.200	0.896
let-7c-5p	314	162	19	24	5	1.400	2.874	0.158	0.052
miR-100-5p	11	17	44	0	0	–	–	–	–
miR-10b-5p	860	57	28	19	12	1.152	1.728	0.663	0.153
miR-125b-5p	514	316	56	50	11	0.851	1.107	0.353	0.727
miR-193a-3p	710	93	0	28	0	1.293	–	0.275	–
miR-19a-3p	243	200	10	18	0	1.058	–	0.794	–
miR-21-5p	825	122	115	41	46	1.237	1.630	0.309	0.016
miR-221-3p	647	159	42	47	14	1.423	1.696	0.053	0.137
miR-350-3p	0	264	0	0	0	–	–	–	–
miR-99a-5p	925	10	24	6	13	3.107	2.448	0.088	0.030

^a2,842 differentially expressed genes in total

^bIndicates the degree of enrichment/depletion. OR > 1, negatively correlated differentially expressed targets are overrepresented. OR < 1, negatively correlated differentially expressed targets are underrepresented

^cSignificance of enrichment/depletion