Figure 8.

GFAP and Iba-1 reactivity to the chronically implanted fiber catheter and flexible electrode assembly at week 1, 3, and 6, respectively. At week 1 and 3 the GFAP positive cells spread to larger area around the insertion trajectory (1A,B, 2A,B), while at week 6 the GFAP positive cells become less pronounced in the extended surrounding area, instead they construct a compact layer next to the electrode and fiber (1C, 2C). Iba-1 positive cells are much smaller numbers than the GFAP positive cells at all time points (3A–C, 4A–C). No obvious proliferation of the Iba-1 positive cells are observed over time. Row 5 and 6 are the superimposed pictures of GFAP (green), Iba-1 (red) and DAPI (blue) staining. Scale bar = 100 μm.