Figure 4.

Shifts of functional genes in periodontal communities for key metabolic pathways. For each pathway, first, the relative abundance of genes between healthy controls (H) and moderate periodontitis (MP) or severe periodontitis (SP) was compared with analysis of variance (ANOVA; α=0.05). Then, the numbers of genes with statistical difference were counted. The bars represented the percentage (%) of these genes in total genes in this category and * indicated more than 40% genes altered in this category.