Figure 1.

Overview of various therapeutic approaches to reduce ADMA and restore NO bioavailability to prevent the development of hypertension in spontaneously hypertensive rats. The solid lines represent underlying mechanisms contributing to hypertension, and the interrupted lines denote protective effects of different approaches. ADMA, asymmetric dimethylarginine; DDAH, dimethylarginine dimethylaminohydrolase; NADPH, nicotinamide adenine dinucleotide phosphate; DMA, dimethylamine; GSH, glutathione; NOS, nitric oxide synthase; PIN siRNA, silencing RNA targeting protein inhibitor of neuronal nitric oxide synthase; PRMT, protein arginine methyltransferases; RAS, rennin–angiotensin system.