Figure 5.

Analysis of kinases activity. Kinase-substrate relations predicted by iGPS (A) NetworKIN 3; and (B) linear motifs analysis derived from motifs stored in Human proteome reference database (HPRD) database; (C) The color shade corresponds to the value of the “position score” that indicates if the ratios (normalized H/L ratios) of sites phosphorylated by a particular kinase tend to be larger (0 to 1) or lower (−1 to 0) than the rest of the data (p < 0.05), i.e., green color of a region in a heatmap indicates an increased activity of a particular kinase after IR and VE‑821 co-treatment, red color indicates trend of decreased activity.