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. 2014 Jul 8;15(7):12119–12134. doi: 10.3390/ijms150712119

Figure 5.

Figure 5

Cordycepin inhibits ROS (reactive oxygen species) production and NF-κB activation in both LPS-stimulated RAW 264.7 cells and KD patients’ PBMCs. RAW 264.7 cells were pretreated with cordycepin (10 μM, 1 h) or CA-AMPK (2 μg/mL, 48 h), followed by LPS (1.0 μg/mL) stimulation for 2 h, ROS production and p-NFκB/tubulin expression were tested by FACS (A) and western blotting (B), respectively. The ex vivo cultured PBMCs of KD patients/healthy controls were treated with cordycepin (10 μM), with or without LPS (1.0 μg/mL) for 2 h; ROS production and p-NFκB/tubulin expression were tested (C,D). The results presented were representative of three independent experiments. The values were expressed as the means ± SD. # p < 0.05 (A,B).