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Base readout in the major and minor groove. (a) Functional groups of the DNA base pairs in the major and minor DNA groove; (b) Accessibility of functional groups in the major groove in a 16-mer B-DNA; (c) Locally increased readout accessibility in minor groove of bent B-DNA (PDB code 1JJ4); (d) Enlarged binding capability due to kink-induced shape alteration in B-DNA (PDB code 2KEI, [92]). Hydrogen bond donors in blue, acceptors in red and thymine methyl group in green.
