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Free trp operator DNA, and in a complex with the Trp repressor protein, illustrating direct base readout and its impact on DNA structure. Cognate recognition sequences are highlighted in red. (a) Schematic representation of the trp operator-Trp repressor complex (PDB code 1TRO); The 15° bend compresses the major groove in the complex, whereas free DNA (b) (NDB code BDJ061) is straight, highlighting the subtle differences between bound and free DNA.
