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Structure of the Zα-domain of ADAR1 bound to left-handed Z-DNA (PDB code 3IRQ). (a) Schematic representation of the protein-DNA complex, highlighting the surface fit of the two macromolecules. The DNA is shown in gold, with the two bound proteins in green, overlaid with their semi-transparent surface; (b,c) Electrostatic interactions between ADAR1 and the Z-DNA backbone.
