Table 2.
SNPs associated with physical activity with bootstrap selection stability (BSS) ≥95% in top 1000, top 2000, top 3000, and top 4000 SNPs through a multi-stage approach.
| rs Number | Gene Symbol | Location of SNP | Cytoband | Minor Allele | MAF a | Effect Size (4000) b | BSS (4000) c | p-Value d (4000) | ||
|---|---|---|---|---|---|---|---|---|---|---|
| rs10849033 | CCND2, C12ORF5 | intronic | 12p13.32a | C | 0.4886 | 19.799 | 99.7 | 0.00003 | ||
| rs4252821 | CCNI | Downstream (500 bp) Upstream (5000 bp) |
4q21.1b | G | 0.1013 | 15.281 | 96.9 | 0.00003 | ||
| rs853334 | FGD5, C3ORF20 | intronic | 3p24.3e | A | 0.4373 | −15.166 | 98.3 | 0.00009 | ||
| rs17099857 | ARHGAP26 | intergenic | 5q31.3e | C | 0.0763 | 16.107 | 99.2 | 0.00010 | ||
| rs4906747 | ATP10A | intergenic | 15q12a | G | 0.0640 | 14.613 | 97.4 | 0.00010 | ||
| rs6030844 | RNU6-1, RNU6-2 | intergenic | 20q13.11b | C | 0.1729 | 14.352 | 97.6 | 0.00010 | ||
| rs10978130 | PTPRD | intergenic | 9p23d | C | 0.1523 | 23.022 | 99.9 | 0.00013 | ||
| rs10507652 | TDRD3 | intergenic | 13q21.2b | T | 0.0536 | −19.779 | 99.9 | 0.00015 | ||
| rs7649230 | HES1 | intergenic | 3q29c | C | 0.3382 | 12.115 | 96.4 | 0.00017 | ||
| rs13106655 | TMEM156 | nonsynonymous | 4p14c | G | 0.2674 | 13.811 | 98.2 | 0.00018 | ||
| rs16953182 | UNC13C | intronic | 15q21.3b | G | 0.0165 | 17.941 | 99.2 | 0.00021 | ||
| rs7976955 | VWF, TMEM16B | utr-variant-3-prime | 12p13.31e | T | 0.0230 | 12.674 | 95.5 | 0.00025 | ||
| rs2586038 | MRPS23 | intergenic | 17q22d | G | 0.3314 | −14.089 | 97.1 | 0.00026 | ||
| rs9833833 | UBE2E1 | intergenic | 3p24.3a | T | 0.3393 | 16.227 | 99.3 | 0.00031 | ||
| rs41455146 | ADAM12 | intergenic | 10q26.2a | G | 0.0726 | −12.430 | 96.5 | 0.00033 | ||
| rs2314612 | GPR149, MME | intronic | 3q25.2c | A | 0.4665 | −20.284 | 99.6 | 0.00033 | ||
| rs10513868 | DLGAP1, FLJ35776 | intronic | 18p11.31e | G | 0.2335 | 13.314 | 97.6 | 0.00035 | ||
| rs4131468 | MBD2, DCC, SNORA30, SNORA37 | intergenic | 18q21.2c | T | 0.4954 | −15.354 | 98.8 | 0.00036 | ||
| rs2851651 | intergenic | 11q22.1a | T | 0.2047 | −15.510 | 99 | 0.00039 | |||
| rs2728504 | ZNF521 | intergenic | 18q11.2d | T | 0.2713 | −19.259 | 96.9 | 0.00042 | ||
| rs17339892 | MCTP1 | intergenic | 5q15c | T | 0.1076 | 12.451 | 96.6 | 0.00051 | ||
| rs7997236 | FAM155A | intergenic | 13q33.3a | A | 0.0498 | −20.321 | 99.7 | 0.00054 | ||
| rs1387243 | FAR2, RN5S1, CCDC91 | intergenic | 12p11.22b | C | 0.1766 | 12.015 | 98.4 | 0.00056 | ||
| rs707586 | AJAP1 | intergenic | 1p36.31b | G | 0.2672 | −18.571 | 99.7 | 0.00064 | ||
| rs4978521 | ZFP37, SLC46A2 | intergenic | 9q32b | T | 0.0886 | −19.155 | 96.7 | 0.00066 | ||
| rs2067730 | NRXN3 | utr-variant-3-prime | 14q31.1a | C | 0.0308 | −11.340 | 96.2 | 0.00072 | ||
| rs16967978 | LOC100132540, LOC339047, XYLT1 | intronic | 16p12.3c | A | 0.0427 | 13.550 | 95.2 | 0.00073 | ||
| rs41351947 | EIF2B3 | intergenic | 1p34.1d | C | 0.0291 | −15.446 | 99.2 | 0.00073 | ||
| rs931701 | BOC | intronic | 3q13.2b | A | 0.3798 | −15.920 | 98.9 | 0.00077 | ||
| rs729239 | RNU6-1, RNU6-2 | intronic | 4q21.1b | T | 0.0194 | −15.186 | 98.4 | 0.00080 | ||
| rs10020466 | RN5S1 | intronic | 4q34.3d | C | 0.0739 | −13.149 | 98.4 | 0.00082 | ||
| rs1536053 | C13ORF16 | intronic | 13q34b | T | 0.0393 | −15.016 | 96.8 | 0.00083 | ||
| rs17553316 | RGNEF | intergenic | 5q13.2c | G | 0.0192 | 12.629 | 96.7 | 0.00094 | ||
| rs445942 | C7ORF10, INHBA | intronic | 7p14.1b | C | 0.1666 | −16.716 | 99 | 0.00099 | ||
| rs17058450 | FAM116A | intergenic | 3p14.3a | T | 0.0742 | −12.336 | 96.1 | 0.00103 | ||
| rs11167061 | FLJ43860 | Upstream (5000 bp) | 8q24.3d | A | 0.2238 | −15.508 | 99.2 | 0.00112 | ||
| rs1453282 | intronic | 7p12.3b | C | 0.3057 | −16.260 | 99.5 | 0.00130 | |||
| rs4864029 | RNU6-1, RNU6-2 | intergenic | 4q28.3b | G | 0.1181 | 17.370 | 99.4 | 0.00134 | ||
| rs4620043 | LIFR | intergenic | 5p13.1c | A | 0.2291 | 11.716 | 95.3 | 0.00153 | ||
| rs2140340 | CSMD1 | intronic | 8p23.2c | T | 0.0826 | 15.130 | 98.4 | 0.00177 | ||
| rs3738178 | MOSC1 | intergenic | 1q41d | A | 0.0966 | 13.128 | 96.3 | 0.00189 | ||
| rs7770227 | intergenic | 6q22.1b | T | 0.0781 | 18.199 | 99.7 | 0.00192 | |||
| rs17730347 | MCTP2 | intronic | 15q26.2a | C | 0.2599 | 13.531 | 96.4 | 0.00194 | ||
| rs11024787 | PTPN5 | intronic | 11p15.1c | A | 0.0300 | −18.894 | 99.9 | 0.00200 | ||
| rs1605987 | EDIL3 | intergenic | 5q14.3b | T | 0.1921 | −14.930 | 98.2 | 0.00204 | ||
| rs3802292 | CSMD1 | intronic | 8p23.2d | T | 0.3660 | −15.587 | 99.8 | 0.00238 | ||
| rs2273635 | KIAA1305 | intronic | 14q12a | T | 0.0956 | 13.632 | 97.8 | 0.00243 | ||
| rs7102454 | CFL1, OVOL1, SNX32 | intronic | 11q13.1d | C | 0.3163 | −13.331 | 96.8 | 0.00299 | ||
| rs2725795 | C15ORF53 | intergenic | 15q14d | G | 0.0710 | 17.092 | 99.2 | 0.00323 | ||
| rs2280732 | PLB1 | intergenic | 2p23.2b | C | 0.2716 | 11.855 | 97.2 | 0.00324 | ||
| rs3025365 | DBH, FAM163B | intergenic | 9q34.2a | C | 0.1761 | 11.904 | 95.1 | 0.00326 | ||
| rs6979515 | NXPH1 | intergenic | 7p21.3d | G | 0.3828 | −18.242 | 99.2 | 0.00364 | ||
| rs12332121 | RPS17P2 | intronic | 5q23.1a | C | 0.1237 | −15.236 | 98.4 | 0.00445 | ||
| rs10046269 | EYA4, TCF21 | intergenic | 6q23.2c | C | 0.0454 | 17.753 | 99.4 | 0.00484 | ||
| rs4921144 | MIR146A, ATP10B | Upstream (5000 bp) | 5q33.3d | A | 0.0454 | −12.473 | 96.4 | 0.00495 | ||
| rs888053 | VIT, STRN | intronic | 2p22.2b | A | 0.2656 | 14.279 | 96.5 | 0.00512 | ||
| rs1079082 | ZNF579, FIZ1 | intronic | 19q13.42c | T | 0.1132 | 13.545 | 96.4 | 0.00589 | ||
| rs4531650 | EGLN3, C14ORF147 | intronic | 14q13.1c | C | 0.3818 | −14.878 | 98.3 | 0.00643 | ||
| rs1799884 | GCK, YKT6 | intergenic | 7p13d | A | 0.1892 | −11.829 | 96.7 | 0.00724 | ||
a MAF stands for Minor allele frequency; b Effect size obtained from top 4000 SNPs; c BSS in top 4000 SNPs; d p-values from multiple regression.