Table 3.
Stratified analysis of association between rs10505477 polymorphism and overall survival of gastric cancer.
| Variables | Genotypes (Dominant Model) | HR (95% CI) a | p Heterogeneity | |
|---|---|---|---|---|
| GG | GA/AA | |||
| Total (n = 909) | 315 | 594 | 1.150 (0.937–1.411) | 0.177 |
| Tumor size | ||||
| ≤5 cm | 202 | 362 | 1.248 (0.949–1.640) | 0.112 |
| >5 cm | 113 | 232 | 0.989 (0.726–1.348) | 0.945 |
| Tumor site | ||||
| Non-Cardia | 207 | 394 | 1.226 (0.951–1.581) | 0.116 |
| Cardia | 108 | 200 | 1.038 (0.733–1.469) | 0.835 |
| Lauren classification | ||||
| Intestinal type | 145 | 242 | 0.996 (0.715–1.387) | 0.98 |
| Diffuse type | 170 | 352 | 1.224 (0.941–1.593) | 0.132 |
| Differentiation | ||||
| Well to moderate | 114 | 183 | 0.988 (0.689–1.418) | 0.949 |
| Poorly | 160 | 312 | 1.102 (0.835–1.454) | 0.494 |
| Mucinous/signet-ring cell | 19 | 46 | 2.075 (0.850–5.065) | 0.109 |
| Others | 22 | 53 | 1.674 (0.754–3.718) | 0.206 |
| Depth of invasion | ||||
| T1 | 66 | 111 | 1.072 (0.634–1.813) | 0.796 |
| T2 | 47 | 83 | 1.502 (0.842–2.680) | 0.168 |
| T3 | 2 | 4 | 0.627 (0.138–2.837) | 0.544 |
| T4 | 194 | 384 | 1.115 (0.872–1.425) | 0.385 |
| Lymph node metastasis | ||||
| N0 | 137 | 222 | 1.181 (0.842–1.655) | 0.335 |
| N1/N2/N3 | 170 | 369 | 1.135 (0.877–1.469) | 0.336 |
| Distant metastasis | ||||
| M0 | 309 | 582 | 1.130 (0.914–1.398) | 0.259 |
| M1 | 6 | 10 | 1.544 (0.721–3.305) | 0.264 |
| TNM stage | ||||
| I | 93 | 149 | 1.238 (0.789–1.942) | 0.352 |
| II | 64 | 195 | 1.032 (0.640–1.664) | 0.896 |
| III | 150 | 299 | 1.080 (0.826–1.412) | 0.574 |
| IV | 8 | 14 | 2.301 (0.600–8.818) | 0.224 |
| Chemotherapy | ||||
| No | 208 | 410 | 1.144 (0.893–1.466) | 0.286 |
| Yes | 107 | 184 | 1.414 (0.792–1.645) | 0.478 |
Abbreviations: HR, hazard ratio; CI, confidence interval; a Hazard Ratio (HR) adjusted for age, sex.