Table 2.

Biochemical parameters of male 8- to 10-wk-old leptin-receptor-deficient db/db mice, db/+, and ^IECLEPR-B-WT control mice and ^IECLEPR-B-KO mice

Parameter	Leprdb/+	Lepr db/db	IECLEPR-B WT	IECLEPR-B KO
Body weight (g)	21.6 ± 0.15	42.9 ± 0.86*	23.5 ± 1.43	22.8 ± 1.3
Fat mass (%)	13.0 ± 0.18	29.4 ± 0.48*	11.2 ± 0.60	11.9 ± 0.40
Small intestine (cm)	39.4 ± 1.60	50.8 ± 0.55**	39.3 ± 1.2	40.3 ± 1.35
Large intestine (cm)	8.22 ± 0.50	10.2 ± 0.43***	6.60 ± 0.20	7.04 ± 0.62
Fasting glycemia (mM)	6.51 ± 0.41	24.3 ± 1.52*	7.54 ± 0.59	7.25 ± 0.88
Triglyceridemia (mM)	0.75 ± 0.06	1.45 ± 0.27***	1.44 ± 0.47	0.94 ± 0.19#
HDL-cholesterol (mM)	1.02 ± 0.28	1.05 ± 0.27	1.18 ± 0.20	0.99 ± 0.34
Total cholesterol (mM)	ND	ND	1.23 ± 0.21	1.13 ± 0.22
ALAT (UI)	62.5 ± 20.3	230.4 ± 26.2**	96 ± 37.1	83.2 ± 27.8
ASAT (UI)	364 ± 107.3	304 ± 93.6	260 ± 40.5	315 ± 19.9

Results are means ± se of n ≥ 6/group. Data were analyzed by 1-way ANOVA followed by a multiple comparison Tukey-Kramer test. ND, not determined.

^*P < 0.05,

^**P < 0.01,

^***P < 0.001 vs. db/+;

^#P < 0.05 vs. WT.