Figure 5.

Dex induces adipocyte formation in injured muscle through suppression of IL-4 expression. A) IL-4 mRNA was evaluated from control or injured muscle of mice with or without Dex treatment by RT-PCR (n=3 mice/group). *P < 0.05 vs. control (Ctrl) no Dex. B) TA muscles of IL-4-KO and C57/BL6 mice were injured with CTX; 5 or 7 d later, the cross-sections of TA muscle were H&E stained. C) TA muscles of IL-4-KO and C57/BL6 mice were injured with CTX; 5 d later, the cross-sections of TA muscle were immunostained with anti-eMyHC (green) and perilipin (red). D) mRNAs of C/EBPα and PPARγ were measured from injured or control TA muscle of control or IL-4-KO mice (n=4)., *P < 0.05 vs. control mice. E) mRNA of IL-6 was measured from injured or control TA muscle of control or IL-4-KO mice (n=4),.*P < 0.05 vs. control mice.