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. 2014 Aug 21;5:286. doi: 10.3389/fgene.2014.00286

FIGURE 1.

FIGURE 1

The mammalian carbon catabolite repression 4 (CCR4)–negative on TATA-less (NOT) complex exerts deadenylase activities guided by RNA-binding proteins, miRISC and Tob. (A) Schematic structural organization of the mammalian CCR4–NOT complex. It comprises either of CNOT6/6L and either of CNOT7/8 as deadenylase subunits. (B) Schematic representation of deadenylation by the mammalian CCR4–NOT complex. The CCR4–NOT complex is recruited to the 3′UTR of specific mRNAs through an interaction with AU-rich RNA binding proteins (AUBP) including TTP. GW182 is a component of miRISC together with miRNA and AGO. The CCR4–NOT complex is involved in the miRNA-induced deadenylation through an association with GW182. Tob also interacts with poly(A)-binding protein (PABP) and polyadenylation element-binding protein (CPEB), and recruits the CCR4–NOT complex to initiate deadenylation.