Table 1.

Phenotypes of KO mice of the CCR4–NOT complex subunits.

Gene	Genotype	Dysregulation in the molecular functions	Biological anomaly	Reference
Cnot3	-/-	Unknown	Embryonic lethality (E6.5)	Neely et al. (2010), Morita et al. (2011)
	+/-	Up-regulation of Pdk4 and Igfbp1 mRNA	Leanness	Morita et al. (2011)
		Up-regulation of Rank mRNA	Osteopenia	Watanabe et al. (2014)
		Transcriptionally inactive chromatin	Cardiac dysfunction	Neely et al. (2010)
Cnot7	-/-	Impaired Rxrb signaling	Male sterility	Berthet et al. (2004), Nakamura et al. (2004)
		Enhanced BMP signaling	Increased bone mass	Washio-Oikawa et al. (2007)