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. 2014 Aug 21;4:104. doi: 10.3389/fcimb.2014.00104

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Copyright © 2014 Milner, Whitten, Kamiza, Carr, Liomba, Dzamalala, Seydel, Molyneux and Taylor.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative images of pathology outside of the brain are shown. The lungs (A) demonstrate some sequestration of parasites but more frequently have heavily burdened macrophages with variable size pigment globules (1000X, H&E). Fibrin thrombi (B) were present in a subset of CM2 and other cases in the lungs suggestive of DIC (400X, H&E). The spleen (C) in a patient with CM after depigmentation of the section using picric acid followed by Giemsa stain (from Milner, unpublished data) demonstrating the unique finding of dense parasite burdens in CM1 spleens (200X, Giemsa). A representative glomerulus (D) from the kidney shows malaria pigment within macrophages and microthrombi present in capillaries (400X, H&E).