Table 1.
Patient characteristics at first-line ART failure
| Total (%) | No multi-NRTI mutations (%) | Multi-NRTI mutations (%) | |
|---|---|---|---|
|
| |||
| n=105 (100) | n=66 (63) | n=39 (37) | |
| Age at genotyping (years) | |||
| Median (IQR) | 36 (32–41) | 35 (32–40) | 37 (33–42) |
| ≤30 | 19 (18) | 13 (20) | 6 (15) |
| 31–40 | 59 (56) | 38 (58) | 21 (54) |
| 41+ | 27 (26) | 15 (23) | 12 (31) |
| Sex | |||
| Male | 69 (66) | 43 (65) | 26 (67) |
| Female | 36 (34) | 23 (35) | 13 (33) |
| Mode of exposure | |||
| Heterosexual contact | 76 (72) | 47 (71) | 29 (74) |
| Homosexual contact | 19 (18) | 15 (23) | 4 (10) |
| Other/unknown | 10 (10) | 4 (6) | 6 (15) |
| VL at genotyping (copies/ml) | |||
| Median Log10 VL (IQR) | 4.14 (3.65–4.94) | 4.02 (3.55–4.91) | 4.52 (3.95–5.00) |
| ≤10,000 | 44 (42) | 33 (50) | 11 (28) |
| 10,001–100,000 | 38 (36) | 20 (30) | 18 (46) |
| >100,000 | 23 (22) | 13 (20) | 10 (26) |
| CD4 at genotyping (cells/µL) | |||
| Median (IQR) | 172 (75–278.5) | 206.5 (121–300.5) | 83.5 (16.5–194.5) |
| ≤200 | 58 (55) | 30 (45) | 28 (72) |
| >200 | 38 (36) | 30 (45) | 8 (21) |
| Missing | 9 (9) | 6 (9) | 3 (8) |
| Years since ART initiation | |||
| Median (IQR) | 2.17 (1.07–3.91) | 1.56 (0.81–3.58) | 2.88 (2.09–4.29) |
| ≤2 | 49 (47) | 40 (61) | 9 (23) |
| >2 | 56 (53) | 26 (39) | 30 (77) |
| Failing ART | |||
| NRTI+NNRTI | 99 (94) | 62 (94) | 37 (95) |
| NRTI+PI | 6 (6) | 4 (6) | 2 (5) |
| Failing NRTI | |||
| 3TC+d4T | 46 (44) | 27 (41) | 19 (49) |
| 3TC+AZT | 33 (31) | 17 (26) | 16 (41) |
| Other | 26 (25) | 22 (33) | 4 (10) |
| Previous AIDS | |||
| No | 46 (44) | 36 (55) | 10 (26) |
| Yes | 59 (56) | 30 (45) | 29 (74) |
| Subtype | |||
| B | 17 (16) | 9 (14) | 8 (21) |
| Non-B | 88 (84) | 57 (86) | 31 (79) |