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. 2014 Aug 21;4:6152. doi: 10.1038/srep06152

Figure 1. IC50 values for cell lines.

Figure 1

Cell viability of the mesothelial, parental and chemo-resistant mesothelioma cells were assessed using MTT assays in the presence of therapeutic agent as indicated. The drug dose causing 50% growth inhibition (IC50 drug dose) was calculated. While the 4/4 RM.4 cells grew significantly slower than the II-45 cells (p < 0.05) with doubling times of 18.1 ± 0.9 hrs and 14.5 ± 0.9 hrs respectively, the percentage survival for the cytotoxicity assays is based on the growth of each individual cell line grown without the addition of chemotherapeutic agent and is thus independent of differences in growth rates between the cell lines. Bars show the mean and the error bars show the standard error from at least three independent experiments. P-value was calculated using a one-way Anova test with a value of less than 0.05 indicating significance.*p < 0.05, ** p < 0.01, *** p < 0.001 relative to parental II-45 mesothelioma cells. Mesothelial cells, 4/4 RM.4, parental mesothelioma cells, II-45; cisplatin resistant II-45 cells, CisR; pemetrexed resistant II-45 cells, PemR; combination (cisplatin + pemetrexed) resistant II-45 cells, ComboR; gemcitabine resistant II-45 cells, GemR; vinorelbine resistant II-45 cells, VLBR.