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. 2014 Aug 21;4:6152. doi: 10.1038/srep06152

Figure 4. Histological images of pleural tumors derived from parental and chemo-resistant II-45 cells.

Figure 4

Representative images arranged according to morphological characteristics (a). Tumors with a distinctive epithelioid appearance are on the left ranging towards essentially sarcomatoid tumors on the right. GemR, gemcitabine resistant II-45 cells; CisR, cisplatin resistant II-45 cells; VLBR, vinorelbine resistant II-45 cells; II-45, parental mesothelioma cells; PemR, pemetrexed resistant II-45 cells; ComboR, combination (cisplatin + pemetrexed) resistant II-45 cells. Scale bar = 50 μm. Podoplanin immunolabeling of tumors derived from parental (b) II-45 cells or pemetrexed resistant cells (c). Membranous immunolabeling of tumor cells and lymphatics (note lack of labelling of endothelial cells lining blood vessel) were identified in both tumor types with the labelling intensity increasing in the pemetrexed resistant tumors with labelling extending internally from the periphery. Inserts: 2× higher magnification; Scale bar = 50 μm.