Table 1.
Agent | Target (IC50) |
---|---|
AMG900 | Aurora A (5 nM) |
Aurora B (4 nM) | |
Aurora C (1nM) | |
MLN8237 | Aurora A (61 nM) |
AZD1152 | Aurora A (1369 nM) |
Aurora B (.36 nM) | |
Aurora C (17 nM) | |
PHA-739358 | Aurora A (13 nM) |
Aurora B (79 nM0 | |
Aurora C (61 nM) | |
Tozasertib | Aurora A (0.6 nM) |
Aurora B (18 nM) | |
Aurora C (4.5 nM) | |
AT9283 | Aurora A (3 nM) |
Aurora B (3 nM) | |
ENMD2076 | Aurora A (13 nM) |
Aurora B (350 nM) |