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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Bioanalysis. 2014 Jun;6(11):1497–1508. doi: 10.4155/bio.14.100

Figure 2. Desorption electrospray ionization-MS imaging of surgical sample, astrocytoma grade IV, showing regions of heterogeneity as recognized by histopathological evaluation.

Figure 2

(A) Desorption ESI (DESI)-MS ion images showing the distribution of m/z 834.3, m/z 885.4 and m/z 788.3, and optical image of H&E-stained tissue section. DESI-MS spectra of (B) low tumor cell concentration region infiltrating into gray matter (delineated in green in the same ion image) and (C) dense tumor region (delineated in red in the m/z 788.3 ion image), with high tumor cell concentration.

H&E: Hematoxylin and eosin.

Reproduced with permission from [30].