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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Bioanalysis. 2014 Jun;6(11):1497–1508. doi: 10.4155/bio.14.100

Figure 4. Improvement of the sensitivity using on-paper chemical derivatization.

Figure 4

(A) Paper spray MS analysis of cholesterol in human serum with (B) blank paper and (C) paper preloaded with betaine aldehyde chloride (5 μl, 100 μg/ml). A total of 2 μl of human serum spotted onto the paper and 10 μl of ACN/CHCl3 (1:1, v:v) utilized as solvent for paper spray.

BA: Betaine aldehyde; HV: High voltage; M: Molecular.

Adapted with permission from [43].