TABLE 2.
Patient | Adrenal Imaging | Plasma Corticotropin | Serum Cortisol | Urinary Free Cortisol | Serum Cortisol Circadian Rhythm | High-Dose Dexamethasone Sppression Test |
---|---|---|---|---|---|---|
1 | MRI: bilateral nodular enlargement | ↓ | ↑ | ↑ | NA | NA |
2 | CT: R adrenal 15 × 9 mm; L gland not seen | ↓ | ↑ | NA | Absent | NA |
3† | CT and MRI: asymmetrical bilateral enlargement, L>R | ↓ | ↑ | ↑ | Present‡ | Cortisol not suppressed |
4 | Angiogram: L vascular mass | NA | Normal | NA | NA | Cortisol not suppressed |
5 | NA | NA | ↑ | ↑ | NA | Cortisol not suppressed |
6 | Scintigram: marked uptake bilaterally, L>R | ↓ | NA | ↑ | Absent | NA |
7 | CT: bilateral enlargement | ↑ | ↑ | NA | NA | Cortisol not suppressed |
8 | NA | ↓ | ↑ | Absent | Cortisol not suppressed | |
9 | US and MRI: R, multinodular enlargment; L, normal | ↓ | ↑ | NA | Absent | Cortisol not suppressed |
10 | Aortogram: no adrenal enlargement | ↓ | ↑ | ↑ | NA | Cortisol not suppressed |
Patients 1 through 10 had Cushing syndrome and McCune-Albright syndrome. Patient 10 had Cushing syndrome, but not McCune-Albright syndrome.
Urinary aldosterone secretion was normal.
Following unilateral adrenalectomy.
↓ indicates decreased or undetectable; ↑, increased; CT, computed tomography; L, left; MRI, magnetic resonance imaging; NA, not available; NMR, nuclear magnetic resonance; R, right; US, ultrasonography.