TABLE 4.
Adrenal Weight, g
|
Microscopic Pathology
|
||||||
---|---|---|---|---|---|---|---|
Patient | Right | Left | Gross Pathology | Cortical Nodules |
Cortical Hyperplasia |
Cortical Atrophy |
Fetal Cortex |
1 | 4.2 | 4.7 | Slightly nodular, hyperplastic dark green parenchyma | Yes | Acidophilic; cortex up to 1 mm thick | Yes | Present |
2 | NA | NA | NA | No | Acidophilic | Yes | Present |
3 | NA | NA | Cortex thickened; yellow nodules, with darker center, some extra-adrenal | Yes | Clear cell >acidophilic | Yes | Absent |
4 | 9.5 | NA | Marked increase in cortical tissue | Absent. Adenoma bilaterally | Acidophilic | No | Absent |
5 | 3.5 | 4.0 | Smooth outline preserved; cut surface reddish-brown with alternating tan-to-green nodules | Yes, vague | Acidophilic; cortex up to 1.2 mm thick | Yes | Present |
6 | 3 | 3.2 | NA | Yes | Acidophilic | Yes | Present. Cytomegaly and cortical cysts |
7 | 1.5 | 2.0 | R: Tan nodule, 4 × 2 × 2 cm | Yes | Clear cell >Acidophilic | Yes | |
8 | 1.8 | 2.0 | Small yellow nodules, 2–3.5 mm. Residual cortex brown | Yes | Acidophilic | Yes | Present |
9 | 4 | Not resected | Yellow-gray cortex 0.05 cm thick | Yes | Acidophilic with cortex up to 0.6 mm thick† | Yes | Present |
10 | 2.6 | 2.3 | Cortices slightly thickened | Yes | Clear and acidophilic | Yes | Absent |
Patients 1 through 9 had Cushing syndrome and McCune-Albright syndrome. Patient 10 had Cushing syndrome, but not McCune-Albright syndrome.
Prominent accumulations of zona glomerulosa-type cells around periphery of gland.
NA indicates not available; R, right.