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. Author manuscript; available in PMC: 2015 Jan 10.
Published in final edited form as: Nature. 2014 Jun 1;511(7508):251–254. doi: 10.1038/nature13292

Figure 1. Genome stability maintenance role of Srs2 helicase in rnh202Δ cells.

Figure 1

a. Strains harboring either the srs2-860 allele or its helicase null K41A variant at the chromosomal SRS2 locus were constructed. b. Doubling times. c. Spontaneous mutation rates. d. Recombination rates. e. Sensitivity to hydroxyurea (HU). f. Synthetic interaction of the pol2M644G mutation in the rnh202Δ srs2Δ background. g. Mutation spectra of CanR mutants obtained in (c). h. Dinucleotide slippage rates. Plotted in (b) are the mean values±s.d., n=3. Plotted in (c), (d) and (h) are median rates with error bars representing 95% confidence intervals29; n=18.