Table 5.
Stratified analysis to study the relation between endothelial nitric oxide synthase (eNOS) gene polymorphisms and the risk of hypertension in the subgroups with selected habits in the study population.
| eNOS gene polymorphism | Parameter | Odds ratio (95% CI) |
P value | |
|---|---|---|---|---|
| eNOS gene intron 4 ab polymorphism | Tobacco use (either smoking/chewing or both) | Subjects who have the habit of tobacco use (either smoking/chewing or both) with eNOS4 aa genotype | 14.00 (1.20–163.37) |
0.035∗ |
| Subjects who have the habit of tobacco use (either smoking/chewing or both) with eNOS4 ab genotype | 8.06 (4.41–14.73) |
0.000∗ | ||
| Subjects who have the habit of tobacco use (either smoking/chewing or both) with eNOS4 bb genotype | 4.09 (2.73–6.12) |
0.000∗ | ||
| Alcohol consumption | Subjects who have the habit of alcohol consumption with eNOS4 aa genotype | 12.00 (1.20–143.73) |
0.035∗ | |
| Subjects who have the habit of alcohol consumption with eNOS4 ab genotype | 1.56 (0.91–2.65) |
0.105 | ||
| Subjects who have the habit of alcohol consumption with eNOS4 bb genotype | 2.07 (1.41–3.04) |
0.000∗ | ||
|
| ||||
| eNOS gene exon 7 Glu298Asp polymorphism | Tobacco use (either smoking/chewing or both) | Subjects who have the habit of tobacco use (either smoking/chewing or both) with eNOS7 GG genotype | 5.56 (3.72–8.31) |
0.000∗ |
| Subjects who have the habit of tobacco use (either smoking/chewing or both) with eNOS7 GT genotype | 3.86 (1.95–7.67) |
0.000∗ | ||
| Subjects who have the habit of tobacco use (either smoking/chewing or both) with eNOS7 TT genotype | 2.29 (0.27–19.66) |
0.451 | ||
| Alcohol consumption | Subjects who have the habit of alcohol consumption with eNOS7 GG genotype | 1.95 (1.35–2.81) |
0.000∗ | |
| Subjects who have the habit of alcohol consumption with eNOS7 GT genotype | 2.41 (1.24–4.69) |
0.009∗ | ||
| Subjects who have the habit of alcohol consumption with eNOS7 TT genotype | 1.09 (0.13–9.12) |
0.936 | ||
|
| ||||
| eNOS gene T786C polymorphism | Tobacco use (either smoking/chewing or both) | Subjects who have the habit of tobacco use (either smoking/chewing or both) with eNOS T786C TT genotype | 5.84 (3.79–8.98) |
0.000∗ |
| Subjects who have the habit of tobacco use (either smoking/chewing or both) with eNOS T786C TC genotype | 4.51 (2.69–7.56) |
0.000∗ | ||
| Subjects who have the habit of tobacco use (either smoking/chewing or both) with eNOS T786C CC genotype | 9.00 (1.14–71.04) |
0.037∗ | ||
| Alcohol consumption | Subjects who have the habit of alcohol consumption eNOS T786C TT genotype | 2.07 (0.47–3.06) |
0.547 | |
| Subjects who have the habit of alcohol consumption with eNOS T786C TC genotype | 1.75 (0.18–2.86) |
0.084 | ||
| Subjects who have the habit of alcohol consumption with eNOS T786C CC genotype | 2.92 (0.41–20.90) |
0.287 | ||
∗Statistically significant (P value ≤ 0.05).
CI: confidence interval.