Table 2.
Genotypic and allelic distribution of the E23K variant in Tunisian patients with Type 2 diabetes and control subjects.
| Genotype distribution | Allele | Allelic exact test | Global model | Additive model | Dominant model | Recessive model | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T2DM patients (94 men/156 women) | Control subjects (105 men/162 women) | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | ||
| EE | 142 (55/87) (56.8%) | 173 (65/108) (64.79%) | 0.063∗ | 1.00 | |||||||||
| EK | 89 (33/56) (35.6%) | 86 (34/52) (32.21%) | 0.416∗ | 1.44 (0.94–2.2) | 0.092 | ||||||||
| KK | 19 (6/13) (7.6%) | 8 (6/2) (3%) | 0.019∗ | 1.6 (1.14–2.27) | 0.007 | 3.62 (1.26–10.41) | 0.017 | 1.6 (1.07–2.41) | 0.023 | 3.18 (1.11–9.07) | 0.031 | ||
| MAF (K) | 0.254 | 0.19 | 1.44 (1.07–1.93) | 0.015† | 0.017 | ||||||||
| P value for HWE | 0.32 | 0.69 | |||||||||||
Genotype distributions are shown as number (%). MAF: minor allele frequency. *P values comparing genotype distribution between patients with Type 2 diabetes and control subjects. †Allele-specific P values. Odds ratio (OR), 95% CI, and P values were from logistic regression analyses with additive, dominant, and recessive models controlling age, sex, and BMI as covariates. In additive models, ORs are expressed per difference in number of rare alleles.