Table 4.
Association between MTHFR polymorphisms and serum tHcy levels in health controls.
| SNP | M/m | tHcy (μmol/L) | P* | ||
|---|---|---|---|---|---|
| MM | Mm | mm | |||
| rs12121543 | C/A | 12.5 (10.1–14.6) | 11.8 (9.7–13.5) | 10.4 (8.5–14.1) | 0.21 |
| rs13306561 | T/C | 12.1 (9.9–14.4) | 10.5 (8.4–13.7) | 12.3 (10.0–14.4) | 0.87 |
| rs13306553 | T/C | 12.1 (10.0–14.4) | 12.4 (10.0–14.4) | 9.1 (8.1–11.8) | 0.45 |
| rs9651118 | T/C | 12.5 (9.8–14.6) | 12.1 (10.1–14.1) | 11.3 (9.3–13.4) | 0.02 |
| rs1801133 | C/T | 11.3 (9.3–13.7) | 12.8 (10.9–14.4) | 11.9 (9.5–16.6) | 0.0002 |
| rs2274976 | G/A | 12.1 (9.9–14.4) | 12.3 (10.0–14.1) | 10.7 (8.4–13.7) | 0.84 |
| rs4846048 | A/G | 12.4 (10.0–14.4) | 11.4 (9.5–13.3) | 10.7 (8.6–20.1) | 0.28 |
| rs1801131 | A/C | 12.5 (10.1–14.6) | 11.8 (9.7–13.6) | 10.8 (8.6–14.1) | 0.26 |
| rs17037396 | C/T | 12.1 (9.9–14.2) | 12.1 (10.0–14.6) | 13.7 (12.5–15.2) | 0.67 |
*Adjusted for age, sex, BMI, and hypertension.
M indicates major allele; m indicates minor allele.