Table 1.
Clinical features of nine patients with solid organ cancer and pulmonary alveolar proteinosis reported in the literature
| Case/Ref | Sex/age (y) | Presentation | Clinical form | GM-CSF Ab | Cancer | Timing of cancer and PAP |
|---|---|---|---|---|---|---|
| 1/2) |
M/24 |
Weight loss |
Unknown |
N.A. |
Melanoma |
Co-incident |
| 2/3) |
M/64 |
Lt. hemiplegia |
Unknown |
N.A. |
Glioblastoma |
Cancer first |
| 3/4) |
M/67 |
Cough, Sputum |
Unknown |
N.A. |
Lung cancer (SCC) |
Co-incident |
| 4/5) |
M/59 |
Cough, Dyspnea |
Unknown |
N.A. |
Lung cancer (SCC) |
Co-incident |
| 5/6) |
M/45 |
Chest pain |
Unknown |
N.A. |
Mesothelioma |
PAP first |
| 6/7) |
F/54 |
Dyspnea |
Autoimmune |
Positive |
Lung cancer (Adeno) |
PAP first |
| 7/7) |
F/59 |
Dyspnea |
Unknown |
N.A. |
Lung cancer (Adeno) |
Co-incident |
| 8/8) |
M/57 |
Cough, Sputum |
Secondary |
Negative |
Lung cancer (SCC) |
PAP first |
| 9/our case | F/48 | Asymptomatic | Autoimmune | Positive | Breast cancer | Co-incident |
GM-CSF Ab, granulocyte-macrophage colony-stimulating factor antibody; PAP, pulmonary alveolar proteinosis; N.A., not available; SCC, squamous cell carcinoma; Adeno, adenocarcinoma.