Table 1. Summary of published reports evaluating ALK and ROS1 rearrangements in tumors of the gastrointestinal system.

Gene	Reference	Tumor Type	Technology	# Tested	# Positive	Fusion Partner*
ALK	Fukuyoshi et al.(23)	Colorectal Carcinoma	RT-PCR for EML4	96	0	NA
	Takeuchi et al.(8)	Colon Carcinoma	RT-PCR for EML4	48	0	NA
	Lin et al.(9)	Colorectal Carcinoma	Exon-Array Profiling and RT-PCR for EML4	83	2	EML4 E20 and E21
	Karkouche et al.(24)	Colorectal Neuroendocrine Carcinoma	FISH	12	0	NA
	Lipson et al.(27)	Colorectal Carcinoma	Next Generation Sequencing	40	1	C2orf44
	Bavi et al.(25)	Colorectal Carcinoma	FISH	756	0	NA
	Eddy et al.(26)	Full Exome Sequencing	Full Exome Sequencing	NA*	NA*	PRKAR1A, EML4
ROS1	Lee et al.(28)	Gastric Adenocarcinoma	FISH then RT-PCR for identification of fusion partner	495	3	SLC34A2 (×2); 1 unknown
	Gu et al.(29)	Cholangiocarcinoma	Phosphotyrosine signaling profiling (mass spectrometry) followed by 5′RACE	23	2	GOPC (FIG) E3 and E7

NA: Not Applicable;

^*NA: Data not available E: exon of the partner gene fused to ALK or ROS1