FIGURE 2.

Discordance between laterality judgments based on LI estimates and visual inspection of brain activation profiles in three non-sedated patients. Language activity (dipolar) sources are represented as solid red circles projected onto the patients’ MRI, displayed in radiological convention. (A) 9 year-old female with symptomatic partial epilepsy of left temporal lobe origin was deemed to be right dominant for receptive language based on LI (-0.54). Visual inspection of brain activation profiles revealed despite a greater number of activity sources concentrated in the auditory cortex of the right hemisphere, posterior and mesial temporal engagement in the left hemisphere suggested that patient was left dominant for receptive language. (B) 14 year-old female with cryptogenic partial epilepsy of left temporal lobe origin was deemed to be left dominant for receptive language based on LI (0.43). Visual inspection of brain activation profiles revealed despite a greater number of activity sources concentrated in the auditory cortex of the left hemisphere, lateral and mesial temporal engagement in the right hemisphere suggested that patient was right dominant for receptive language. (C) 17 year-old male with idiopathic generalized seizures was deemed to have bilateral representation for receptive language based on LI (0). Visual inspection of brain activation profiles revealed despite an equal number of activity sources bilaterally, posterior middle and mesial temporal engagement in the left hemisphere suggested that patient was left dominant for receptive language.