Table 1.

Drugs approved for the prevention and treatment of osteoporosis

Pharmacologic category	United States	European Union
Bisphosphonate	Alendronate Risedronate Ibandronate Zoledronic acid	Alendronate Risedronate Ibandronate Zoledronic acid Etidronate Clodronateb
RANK ligand inhibitor	Denosumab	Denosumab
SERM	Raloxifene	Raloxifene Bazedoxifenea
Parathyroid hormone and derivatives	Teriparatide	Teriparatide Parathyroid hormone
Other	Estrogen/HRT Calcitonin Vitamin D	HRT Strontium ranelate Calcitonin Vitamin D and derivatives

Notes:

^aAvailable only in Greece, Spain, and Germany

^bapproved for osteoporosis in only some countries Data from Kanis et al,¹⁷ health.ny.gov,²³ and nof.gov.²⁴

Abbreviations: HRT, hormone replacement therapy; RANK, receptor activator of nuclear factor-kappa B; SERM, selective estrogen receptor modulator.