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. 2014 May 6;289(26):18442–18450. doi: 10.1074/jbc.M114.568857

FIGURE 4.

FIGURE 4.

Biological activity of CV-1 to CV-5, CNTF, CLC, IC-7, IL-6, and LIF on cells expressing IL-6R/gp130 and IL-6R/gp130/LIFR. A, Ba/F3-IL-6R-gp130 cell proliferation assay comparing the bioactivities of CNTF, IL-6, LIF, and CV-1 to CV-5 (1000–0.01 ng/ml). B, Ba/F3-IL-6R-gp130-LIFR cell proliferation assay comparing the bioactivities of CNTF, CLC, IL-6, LIF, IC-7, and CV-1 to CV-5 (1000–0.01 ng/ml). C, analysis of phosphorylation of STAT3 in HepG2 cells by Western blotting comparing the bioactivities of CNTF, CLC, IL-6, LIF, IC-7, and CV-1 to CV-5 (10 and 100 ng/ml). D, analysis of phosphorylation of STAT3 in HepG2 cells comparing the bioactivities of CV-1 to CV-5 (1000 ng/ml).