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Effects of HFD and rosiglitazone on insulin-stimulated sprout formation. Sprouting potential ((number of sprouts/explant)(% of explants sprouting)) of explants derived from mice fed ND or HFD for 30 weeks and treated without or with rosiglitazone (Rosi) for 2 weeks starting at 28 weeks of diet feeding. Statistical significance was assessed by two-tailed paired t tests. **, p < 0.01; ****, p < 0.0001 compared with ND; #, p < 0.05 compared with HFD.
