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. 2014 May 14;289(26):18339–18346. doi: 10.1074/jbc.M114.571091

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FIGURE 6. — Competition between dGTP and GTP for allosteric site 1 during dephosphorylation of dATP by mouse SAMHD1. The experiment shows the changes in SAMHD1 activity by combining increasing concentrations of dGTP with a series of fixed concentrations of GTP as effectors for the dephosphorylation of 30 μm [³H]dATP by 50 ng of mouse SAMHD1. The concentration of GTP used in each curve is color-coded, the abscissa indicates the concentrations of dGTP. The data demonstrate the superiority of GTP as effector and the competition between dGTP and GTP at allosteric site 1. General conditions are as described for Fig. 2.