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. 2014 May 8;289(26):18582–18592. doi: 10.1074/jbc.M114.567420

FIGURE 1.

FIGURE 1.

Comparison of the consensus protein acyltransferase sequences with the amino acid sequence of zDHHC9. A, WebLogo sequence consensus representation of the 51-amino acid DHHC cysteine-rich domain using the 23 human protein acyltransferase protein sequences. The size of the amino acid letter code denotes the amount of conservation at that position; the boldface residues represent a minimum of 90% conservation. B, WebLogo sequence consensus representation of zDHHC9 and related cysteine-rich domains throughout evolution. The consensus is derived from the following: human zDHHC9, zDHHC14, and zDHHC18; S. cerevisiae Erf2; Ciona intestinalis zDHHC14 (GI: 198427890); Nematostella vectensis zDHHC9 (GI: 156377027); Drosophila melanogaster zDHHC9 (GI: 281366130); Strongylocentrotus purpuratis zDHHC14 (GI: 390334287), Amphimedon queenslandica zDHHC14 (GI: 340375495), Schistoma mansoni zDHHC9 (GI: 256084522), and Danio rerio zDHHC9 (GI: 158518002). An asterisk denotes the proposed catalytic cysteine residue of the DHHC motif (DHHC9 C169A). The arrows indicate the mutated positions of two naturally occurring isolates of human zDHHC9 (zDHHC9 R148W and zDHHC9 P150S).