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Model of the TcdB CROP domain bound to a full-length molecule of bezlotoxumab. The C-terminal (left) half of the CROP domain was modeled based on the structure of the B2 peptide. The Fc region of bezlotoxumab is based on a published high-resolution structure of human IgG1. The four putative carbohydrate binding regions are shown in dark blue within the otherwise green CROP domain.
