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. 2014 May 13;289(26):18535–18548. doi: 10.1074/jbc.M114.569087

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 1. — Diagram of Myo19 structure and sequence alignment of Myo19. A, predicted structure of Myo19. The diagram was not drawn to scale. B, sequence alignment of the converter of myosin-5a and Myo19 reveals two inserts in the converter of Myo19. Yellow and blue shades indicate the identical and conserved residues, respectively. Myo5a-Mm, mouse myosin-5a (GI: 115511052); M19-Mm, mouse Myo19 (GI: 254939539); M19-Hs, human Myo19 (GI: 254939537). C, location of the two Myo19-specific inserts in the crystal structure of myosin-5a (PDB code 1W7J). Upper, the head domain of myosin-5a; lower, the expanded view of the converter. The converter is colored green with insert 1 in cyan and insert 2 in red. Insert 1 and 2 are adjacent to each other and insert 2 is adjacent to the tip of the relay helix. D, consensus sequences of CaM-binding IQ motif, IQ motifs of Myo19, and RLC-binding IQ motif of myosin-2 and -18. CaM-IQ, consensus sequence of the six IQ motifs of mouse myosin-5a (GI: 115511052). M19-IQ1, -IQ2, and -IQ3, sequence logo of the consensus sequence of the three IQ motifs of 11 class XIX myosins, including mouse (GI: 254939539), rat (GI: 254939541), human (GI: 254939537), cattle (GI: 254939551), elephant (GI: 344285323), rabbit (GI: 291405654), cat (GI: 410980571), whale (GI: 466018728), chicken (GI: 513216545), Xenopus laevis (GI: 82178330), and zebrafish (GI: 189519181). The sequence shown at the bottom is mouse Myo19. Conserved residues are shown in bold. Underlined residues are not essential for RLC binding (for details see ”Discussion“). RLC-IQ, sequence logo of the consensus sequence of IQ2 motifs of five muscle myosin-2 and two myosin-18, including scallop muscle myosin (GI: 5611), human non-muscle myosin-2a (GI: 47678583), -2b (GI: 219841954), -2c (GI: 116284394), smooth muscle myosin (GI: 46486992), myosin-18a (GI: 24660442), and myosin-18b (GI: 219841774). Sequence logos were generated by an online program, WebLOGO.