Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Symptom improvement
RCT	70 people at high surgical risk (admitted with ASA grades II–IV; APACHE II score of 12 or higher) with acute cholecystitis	Mean time to symptomatic improvement 15 hours with percutaneous cholecystostomy within 8 hours of admission plus early cholecystectomy 55 hours with medical treatment plus delayed cholecystectomy (8 weeks after full recovery)	P = 0.001	Effect size not calculated	percutaneous cholecystostomy plus early cholecystectomy