Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Mortality
Systematic review	70 people at high surgical risk (admitted with ASA grades II–IV; APACHE II score of 12 or higher) with acute cholecystitis Data from 1 RCT	Death 0/37 with percutaneous cholecystostomy plus early cholecystectomy 1/33 with medical treatment plus delayed cholecystectomy	P = 0.47		Not significant